In the small Central California town where they grew up, two estranged gay brothers struggle to reconnect after the recent death of their father.
Forensic psychologist and detective Alex Cross travels to North Carolina and teams with escaped kidnap victim Kate McTiernan to hunt down "Casanova," a serial killer who abducts strong-willed women and forces them to submit to his demands. The trail leads to Los Angeles, where the duo discovers that the psychopath may not be working alone.
A journalist duo go on a tour of serial killer murder sites with two companions, unaware that one of them is a serial killer himself.
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